Feline lectin activity is critical for the cellular entry of feline infectious peritonitis virus.
نویسندگان
چکیده
Feline infectious peritonitis is a lethal disease of felids caused by systemic infection with a feline coronavirus. Here, we report identification and analysis of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent strains of serotype 1 and serotype 2 feline coronaviruses.
منابع مشابه
Antibody detection of feline infectious peritonitis virus (FIPV) in sera of companion cats in Ahvaz, south west of Iran
Feline infectious peritonitis virus (FIPV) is ubiquitous in domestic cats, especially in young cats and multi-cat environments. In the present study, a total of 248 companion cats of different ages were examined for serum antibody detection of FIPV by immunochromatography assay. The cats were selected from those referring to Veterinary Hospital of Ahvaz University, southwestern Iran from Decemb...
متن کاملAttachment and internalization of feline infectious peritonitis virus in feline blood monocytes and Crandell feline kidney cells.
In this study, kinetics of attachment and internalization of feline infectious peritonitis virus (FIPV) serotype I strain Black and serotype II strain 79-1146 were determined in feline monocytes from two cats and in Crandell feline kidney (CrFK) cells. Attached FIPV I (Black) particles were observed on almost all monocytes. Within 1 h, 17 particles were bound per cell and, within 1 min, 89 % of...
متن کاملAntibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human monocyte cell line U937 by serum of cats experimentally or naturally infected with feline coronavirus.
Infection of the type II feline infectious peritonitis virus (FIPV) strain 79-1146 to primary feline alveolar macrophages and human monocyte cell line U937 was enhanced by the sera of cats experimentally infected with the 79-1146 strain, but not those of cats infected with KU-2 or UCD-1 strain of type I FIPV. The experiments using sera of cats with feline infectious peritonitis (FIP) and of cat...
متن کاملANIMAL HEALTH Infectious Diseases Affecting Cats
The most important infectious diseases affecting cats are feline panleukopenia, feline viral respiratory diseases, feline infectious peritonitis, and the feline leukemia virus disease complex. Other infectious diseases affect cats, but do not occur as frequently. Feline Panleukopenia also is variously termed feline infectious enteritis, or cat distemper. It is caused by a parvovirus (DNA virus)...
متن کاملEvaluation of protective efficacy of the synthetic peptide vaccine containing the T-helper 1 epitope with CpG oligodeoxynucleotide against feline infectious peritonitis virus infection in cats.
BACKGROUND Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Cellular immunity is considered to play an important role in the prevention of FIP. Thus, induction of the cellular immune response is essential in vaccines against FIP virus (FIPV) infection. METHODS We immunized cats with peptides containing T-helper (Th)1 epitopes derived...
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ورودعنوان ژورنال:
- Journal of virology
دوره 84 15 شماره
صفحات -
تاریخ انتشار 2010